CAS No.:106096-92-8
Other Names:
rh-aFGF, aFGF,FGF-1,FGF-alpha, Fibroblast Growth Factor-Acidic (rh-aFGF)/afgf/Sh-polypeptide-11
Molecular Formula.:
Molecular Weight: 15.5 Kda
Place of Origin:China (Mainland)
Type:
Grade Standard:Cosmetic Grade
Brand Name:Antibodybio
Model Number:ABC107
Purity: 96.0% Test Method: SDS-PAGE
Shelf life:2 Years Proper Storage
Heavy Metals:≤10 PPM
Appearance:White crystalline powder
Packing:1G/Bottle, 10G/Bottle,50G/Bottle or at customers reqirement.
HS Code:29349930
Fibroblast Growth FactorAcidic (aFGF), also known as FGF1, is a member of the fibroblast growth factor (FGF) family. FGF acidic is a potent mitogenic agent for a wide variety of mesodermderived cells including BALB/c 3T3 fibroblasts, capillary and endocardial endothelial cells, myoblasts, vascular smooth muscle cells, mesothelial cells, glial cells, and adrenal cortex cells. It has a wide range of biological effects and potential clinical applications.FGF acidic has the ability of binding to heparin. And heparin potentiates the actions of aFGFas well as its stability against high temperature, extreme pH degeneration and hydrolysis.
RhaFGF is a a single and nonglycosylated polypeptide chain containing 141 amino acids and having a molecular mass of 16 kDa expressed by E. coli.
Function
1. Anti-wrinkle and Anti-aging
(a) aEGF modulates the skin rejuvenating by kstimulation of cell proliferation
(b) aEGF rejuvenates both the epidermal cells and the underlying fibroblast cells, which produce collagen, elastin, and hyaluronic acid, maintain human skin elasticity, and decrease cutaneous senescence.
(c) The proliferation of epidermal cells enhanced the skin cells regeneration.
2. Wound healing and tissue repair
Angiogenic in vivo, stimulate cell proliferation on human vein endothelial cell, induce the formation of new capillary blood vessels. It binds to heparin, which potentiates its biological activity and protects it from proteolysis.
3. Rejuvenates hair follicle to produce new hair
aFGF can activate FGF-7, promote hair growth by stimulation of cell proliferation on primary hair cell, treat or prevent baldness.
4. Mitogenic for a variety of mesenchymal and neuroectodermal cells
It promotes DNA synthesis, stimulate cell proliferation and differentiation associated with wound healing, angiogenesis, tissue regeneration, embryogenesis and CNS development.
Interactions
Alcohol and iodine may probably destroy the characteristic properties of aFGF which lead to the decrease of its activity. The skin on which Alcohol or iodine are used should be washed with normal saline prior to apply aFGF.